Using crucifix on Seek can be useful in 2023 April Fools Event or if the player runs in the wrong direction.

While the Figure and Seek are also hostile entities, the crucifix cannot banish them. It will only stun them for a period of time.If a player attempts to use the crucifix in The Rooms, there will be a message saying "Your crucifix feels lighter than normal..."

These are based on gameplay experiences and how the crucifix might be useful or not during some situations. This is likely due to the strength of the entities; lore-wise, they are important and powerful antagonists, while game-wise they serve as the most extreme tests of the player's skills, and shouldn't be skipped. Using crucifix on Ambush is effective if there are not enough closets or if a player is unexperienced. The crucifix does not work on April Fools Exclusive Entities (Jeff The Killer, Banana Peel, Greed, Evil Key, Subspace Tripmine). If the player is bad at dealing with entities like Ambush and Halt, they can use the crucifix to banish them.Using the crucifix against either Seek or the Figure will appear to work at first, though the sigil on the floor will suddenly turn red and the trapped entity will be released as a shattering sound is heard. Since it is a powerful one-time item, it should only be equipped when the user is in complete danger. Crucifixes in biblical stories are known for banishing demons or exorcising them, concluding that the entities are demons of some sort. There is a glitch where three players, each holding a crucifix and using it on Seek at the same time, will glitch Seek out of the Hotel, and it will be "banished". The sigil that appears beneath the entity while it is being banished/stunned resembles the Seal of Solomon, otherwise known as a hexagram.

Dupe and Void are currently the only entities that cannot be seen being banished directly. Dupe is only implied that to be banished.However, using the crucifix on Void will restrict it from dealing significant damage to the player. Some people think that when they used the crucifix, they banished Seek. This is actually because when they watch Seek being banished, the chase is still ongoing, multiple doors have been opened, and they have been teleported by Void. If the player is using safespots to hide from either Rush or Ambush, holding the crucifix out while being at the safespot can be a great way to ensure survival, as if in case either Rush or Ambush catches the player at the safespot, the crucifix will be used, saving any and all players hiding at that spot, and if the safespot worked, the crucifix will not activate, which can be saved for later. Attempting to use the crucifix on El Goblino will result in him saying "¡Oye! Watch where you swing that thing, hombre! Uff!" Elevator • Jeff's Shop • The Courtyard • The Dining Room • The Electrical Room • The Grand Hallway • The Greenhouse • The Infirmary • The Library • The Reception

Since the crucifix will not affect any entities inside The Rooms, it's recommended to use it before then. However, if the player is aiming to preserve the Shakelight or NVCS-3000, it's still a good idea to keep it, to reduce the risk of dying before reaching the rift. This message, when translated and ran through the Caesar cipher, reads "OneOfTheThreeArchitectsMarkedByCelestialsAssistsYou." Using a crucifix on Rush is only useful if all closets are taken or a double-rush occurs in the Greenhouse. It is not recommended to use the crucifix on entities such as Dupe or Eyes as such entities are easy to avoid. The crucifix is connected with the Guiding Light, as when it's activated, the chains appear to be the same color as Guiding Light, along the cross turning blue before it disappears. This also applies even if the crucifix is failing to work, though the chains eventually glow red and break.The players cannot use more than one crucifix on one entity. If they attempt to do so only one person's crucifix will be used. It also contains a crescent in the middle of the hexagram, which is depicted as the Islamic crescent. Though to actually depict it, it has to be paired with a five-pointed star. However, a difference of the crucifix from the Totem of Undying is that the crucifix is activated when the player would have taken damage, while the Totem of Undying activates when the player would have died. In the sigil's inner circle is a message in the font "WingDings", a font that displays letters as symbols. If one is in the path of the Figure and they cannot escape it or outrun it, they can use the crucifix to buy them time to escape before the Figure breaks free.