DNLA have protective effects against OGD/RP-induced neuronal damages in rat primary neuron cultures by stabilizing mitochondrial membrane potential, inhibiting intracellular free calcium overload, and lessening neuron apoptosis mediated by down-regulating mRNA expression of caspase-3 and caspase-12 [ 59]. Knowing that Dendrobium drugs have been traditionally used in TCM preparations as a universal remedy, they are worth investigating by scientists who are looking for new natural ingredients, which could become a main feature in healthy aging. Furthermore, this compound was found to induce apoptosis of colorectal cancer HCT-116 cells via tubulin depolymerization and DNA damage stress which leads to the activation of c-Jun NH2-terminal protein kinase and mitochondria-involved intrinsic apoptosis pathway [ 35]. Taking dendrobium along with medications for high blood pressure might cause your blood pressure to go too low. Among other diabetic complications, diabetes-induced cardiomyopathy (DCM) mediated by hyperglycemia can induce the adverse architectural remodeling of heart, and ultimately lead to heart failure and death.

Convenient and Portable: The herbal supplement come in a compact and easy-to-carry bottle for convenient use on-the-go. demonstrated for the first time that gigantol significantly decreases lung cancer cells viability in a detached condition through anoikis and anchorage-independent assays.Moscatilin and 4-(3-hydroxy-4-methoxyphenetyl)-2,6-dimethoxylphenol were the most cytotoxic compounds with IC 50 values range from 2. Moreover, the results indicate that treatment of diabetic rats with DO was effective in improving punctuate mechanical nociception, reduced hypoalgesia and histopathological changes of vital organs induced by hyperglycemia. However, only (-)- and (+)-denobilone A showed moderate inhibitory effects on HeLa, MCF-7, and A459 cells, with IC 50 values of 9. Recently, a bibenzyl-dihydrophenanthrene derivative, named dendrosignatol, together with 3,4-dihydroxy-3,4-dimeth-oxybibenzyl, dendrocandin B, dendrocandin I and dendrofalconerol A, isolated from the whole plant od Dendrobium signatum, showed appreciable cytotoxic activity against three human cancer cell lines, including breast cancer MDA-23 1, liver hepatocellular carcinoma HepG2 and colorectal tumor HT-29 cells [ 51].

showed the antimigratory and anti-metastatic effects of moscatilin on human breast cancer in an MDA-MB-231 metastatic model. How to Use-Use the dropper to absorb 1-2ml(measuring label in the dropperunder the tongue, 3 times a day. This effect appears to be due, at least in part, to suppression of LPS-induced overexpression of hippocampus tumor necrosis factor receptor 1 (TNFR1), possibly through inhibition of phosphorylated p38 mitogen activated protein kinases (p-p38 MAPK) and the downstream NF-κB signal pathway [ 16]. Auxiliary Stability Maintenance -- Herbal lung health essence auxiliary stability maintenance have protective membrane nourishment and purification.Its immunomodulatory activity was evaluated by secretion level of cytokine (IL-1β and IL-10) and TNF-α in vitro. Thanks to scientific progress and awareness of factors related to life style, the population is becoming older. About seventy Dendrobium species are found in China, but only two monographs are found in Chinese Pharmacopoeia (2010 edition) [ 2]. Interestingly, only a high dose of erianin (80 and 160 nM) could inhibit the proliferation of T47D cells.

Dendrobium extracts, polysaccharides and bibenzyls showed promising activities on various anti-diabetic targets ( Table 3). Dendrobium nobile alkaloids (DNLA) were studied for their effects on rat primary cultured neurons subjected to oxygen-glucose deprivation/reperfusion (OGD/RP) in vitro, in an attempt to attenuate neuronal damage in ischemic brain vascular diseases.huoshanense, which exhibits specific functions in activating murine splenocytes to produce several cytokines including IFN-α, IL-10, IL-6, and IL-1α, as well as hematopoietic growth factors GM-CSF and G-CSF [ 90]. Structure analysis indicated that DOP-W3-b was composed of mannose and glucose in a molar ratio of 4.

Western blotting analysis revealed that this compound greatly decreases epithelial to mesenchymal transition (EMT) markers, including N-cadherin, vimentin, and Slug, leading to a significant suppression of protein kinase B, extracellular signal-regulated kinase, and caveolin-1 survival pathways during the detached condition [ 39].

Dendrobium species have been used for a thousand years as first-rate herbs in traditional Chinese medicine (TCM). Denbinobin, at the concentration of 10 µM, prevents chemokine protein CXCL12-induced prostate cancer (PC-3) cell migration by inhibiting Rac1 activity. DOE pretreatment significantly decreased creatine kinase, lactate dehydrogenase, total cholesterol and triglyceride levels, limited the production of malonaldialdehyde and increased the activities of superoxide dismutase. Pre-treatment with DP was further demonstrated to be protective in a dose-dependent manner in response to the TNF-α stimulus. In vitro, the extract induced cytotoxic response in a concentration-dependent manner, with an IC 50 value at 350 µg/mL, against Dalton’s lymphoma (DL) cells [ 24].