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Using MCP for heavy metal detoxification is appealing due to the fact that it may have fewer side effects and be less invasive than other types of chelation therapy. However, a slight decrease in the G0/G1 phase was caused by MCP, leading to substantial cell arrest in G2. In a small trial on 6 healthy volunteers, a pectin-rich unripe apple preparation reduced blood sugar levels after a meal [ 41]. Moreover, MCP inhibited UBC tumor development by causing cell cycle arrest and death in vitro and in vivo.
Leave a comment or connect with me on social media asking any health question you may have and I just might incorporate it into our next listener questions podcast episode just for you! It is expected that many other dietary carbohydrates with immunomodulatory and anticancer effects, such as β-glucans, will have behaviors similar to pectin, and the absorption mechanisms for pectin itself will be examined and discussed in more detail [ 8]. They found potato rhamnogalacturonan I domain-rich pectin (p-RG-I) reduced HT-29 cell growth and caused G2/M cell cycle arrest characterized by decreased CCNB1 and cyclin-dependent kinase 1 ( CDK1) expression.For example, although other chelating agents can effectively remove toxic metals (such as lead) from the body, they can also lower zinc levels, causing a deficiency, particularly in small children [ 2]. Pectin used in the food industry as a gelling agent (for jams and jellies), or as a stabilizer (in sweets, fruit juices, and milk drinks) is mainly extracted from apple pulp or the peel of citrus fruits [ 4, 7, 5]. Several studies have hypothesized that pectin may be used in anti-constipation and anti-diarrhea preparations because of its superior moisturizing properties compared to other types of fiber [ 5].
It had a powerful effect boosting B-lymphocytes, and also the cytoxic effects of T-lymphocytes and Natural Killer (NK) cells against cancer. The purpose of this review is to describe the role of pectin in cancer prevention in depth, progressing from preclinical findings to prospective therapeutic applications.However, apple juice with pectin had no effect on blood pressure in another trial on 23 healthy volunteers [ 57]. However, a review study concluded that only large quantities of certain types of fiber (such as guar gum) can reduce blood sugar, while less viscous fiber, such as pectin, is not effective. Modified citrus pectin (MCP) increases the prostate-specific antigen doubling time in men with prostate cancer: a phase II pilot study. For commercial purposes, it is standard practice to recover pectin from plant material that has been left behind after the juice or sugar has been collected from the plant.